Snx17 (NM_153680) Mouse Recombinant Protein

Product Specifications

Background

Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:12169628, PubMed:16052210) . Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity) . Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity) . Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16052210, PubMed:18276590) . Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns (3P) ) (By similarity) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse sorting nexin 17 (Snx17), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

5830447M19Rik; AI790646; b2b1625.1Clo; D5Ertd260e; mKIAA0064

Gene ID

266781

UniProt

Q8BVL3

Accession Number mRNA

NM_153680

Chromosomal Location

5 B1

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

52.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.