Snx17 (NM_153680) Mouse Recombinant Protein

Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:12169628, PubMed:16052210) . Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity) . Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity) . Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16052210, PubMed:18276590) . Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns (3P) ) (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.