Camk2a (NM_177407) Mouse Recombinant Protein

Product Specifications

Background

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+) /calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity) . Regulates dendritic spine development. Also regulates the migration of developing neurons (By similarity) . Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

CaMKII; mKIAA0968; R74975

Gene ID

12322

UniProt

P11798

Accession Number mRNA

NM_177407

Chromosomal Location

18 34.41 cM

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

54.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.