Kmo (NM_133809) Mouse Recombinant Protein
Product Specifications
Background
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) . Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.[UniProtKB/Swiss-Prot Function]
Synonyms
AI046660
Gene ID
98256
UniProt
Q91WN4
Accession Number mRNA
NM_133809
Chromosomal Location
1 H3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
55 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Kmo
Species
Mouse
Protein ID
NP_598570
Overview
Purified recombinant protein of Mouse kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/98256
Uniprot URL
https://www.uniprot.org/uniprot/Q91WN4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_133809
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_598570
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