Cdc20 (NM_023223) Mouse Recombinant Protein
Product Specifications
Background
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.[UniProtKB/Swiss-Prot Function]
Synonyms
2310042N09Rik; C87100; p55CDC
Gene ID
107995
UniProt
Q9JJ66
Accession Number mRNA
NM_023223
Chromosomal Location
4 D2.1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
54.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Cdc20
Species
Mouse
Protein ID
NP_075712
Overview
Purified recombinant protein of Mouse cell division cycle 20 (Cdc20), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/107995
Uniprot URL
https://www.uniprot.org/uniprot/Q9JJ66
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_023223
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_075712
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