Pias4 (NM_021501) Mouse Recombinant Protein
Product Specifications
Background
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
Pias-gamma; Piasg; PIASY
Gene ID
59004
UniProt
Q9JM05, Q3ULQ6
Accession Number mRNA
NM_021501
Chromosomal Location
10 C1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
55.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Pias4
Species
Mouse
Protein ID
NP_067476
Overview
Purified recombinant protein of Mouse protein inhibitor of activated STAT 4 (Pias4), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/59004
Uniprot URL
https://www.uniprot.org/uniprot/Q9JM05
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021501
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_067476
Curated Selection
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