Mgrn1 (NM_029657) Mouse Recombinant Protein
Product Specifications
Background
E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity) . Acts also as a negative regulator of hedgehog signaling (PubMed:29290584) .[UniProtKB/Swiss-Prot Function]
Synonyms
2610042J20Rik; md; mKIAA0544; nc
Gene ID
17237
UniProt
Q9D074
Accession Number mRNA
NM_029657
Chromosomal Location
16 2.48 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
58.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Mgrn1
Species
Mouse
Protein ID
NP_083933
Overview
Purified recombinant protein of Mouse mahogunin, ring finger 1 (Mgrn1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/17237
Uniprot URL
https://www.uniprot.org/uniprot/Q9D074
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_029657
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_083933
Curated Selection
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