Grb7 (NM_010346) Mouse Recombinant Protein
Product Specifications
Background
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity) . Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.[UniProtKB/Swiss-Prot Function]
Synonyms
MKIAA4028
Gene ID
14786
UniProt
Q03160
Accession Number mRNA
NM_010346
Chromosomal Location
11 61.75 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
60 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Grb7
Species
Mouse
Protein ID
NP_034476
Overview
Purified recombinant protein of Mouse growth factor receptor bound protein 7 (Grb7), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/14786
Uniprot URL
https://www.uniprot.org/uniprot/Q03160
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_010346
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_034476
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