Sgpl1 (NM_009163) Mouse Recombinant Protein
Product Specifications
Background
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:9464245, PubMed:20097939) . Elevates stress-induced ceramide production and apoptosis (PubMed:9464245) . Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793) . Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151) . Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611) . Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse sphingosine phosphate lyase 1 (Sgpl1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AI428538; D10Xrf456; S1PL; Spl
Gene ID
20397
UniProt
Q8R0X7
Accession Number mRNA
NM_009163
Chromosomal Location
10 32.14 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
63.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Sgpl1
Species
Mouse
Protein ID
NP_033189
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/20397
Uniprot URL
https://www.uniprot.org/uniprot/Q8R0X7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_009163
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_033189
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