Sgpl1 (NM_009163) Mouse Recombinant Protein

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:9464245, PubMed:20097939) . Elevates stress-induced ceramide production and apoptosis (PubMed:9464245) . Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793) . Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151) . Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611) . Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.