Ppp1r16b (NM_001159662) Mouse Recombinant Protein

Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS) -induced vascular leakage (PubMed:21907835) . Involved in the regulation of the PI3K/AKT signaling pathway (By similarity) . Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity) . Involved in the regulation of endothelial cell filopodia extension (By similarity) . May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity) . Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity) . Involved in the dephosphorylation of EEF1A1 (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse protein phosphatase 1, regulatory subunit 16B (Ppp1r16b), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug