Nprl3 (NM_181569) Mouse Recombinant Protein
Selected Variant
PM45661M5
Size: 20 µg
Product Specifications
Background
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse nitrogen permease regulator-like 3 (Nprl3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
Aag; CGTHBA; HS-26; HS-40; m (alpha) RE; Mare; Phg; Prox1
Gene ID
17168
UniProt
Q8VIJ8
Accession Number mRNA
NM_181569
Chromosomal Location
11 18.83 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
63.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Nprl3
Species
Mouse
Protein ID
NP_853547
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/17168
Uniprot URL
https://www.uniprot.org/uniprot/Q8VIJ8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_181569
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_853547
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