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Nprl3 (NM_181569) Mouse Recombinant Protein

Product Specifications

Background

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse nitrogen permease regulator-like 3 (Nprl3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

Aag; CGTHBA; HS-26; HS-40; m (alpha) RE; Mare; Phg; Prox1

Gene ID

17168

UniProt

Q8VIJ8

Accession Number mRNA

NM_181569

Chromosomal Location

11 18.83 cM

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

63.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

Nprl3

Species

Mouse

Protein ID

NP_853547

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/17168

Uniprot URL

https://www.uniprot.org/uniprot/Q8VIJ8

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_181569

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_853547

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