Nploc4 (NM_199469) Mouse Recombinant Protein
Product Specifications
Background
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) . Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse NPL4 homolog, ubiquitin recognition factor (Nploc4), transcript variant B, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AK129375; mKIAA1499; Npl4
Gene ID
217365
UniProt
P60670
Accession Number mRNA
NM_199469
Chromosomal Location
11 E2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
64.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Nploc4
Species
Mouse
Protein ID
NP_955763
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/217365
Uniprot URL
https://www.uniprot.org/uniprot/P60670
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_199469
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_955763
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