Trim29 (NM_023655) Mouse Recombinant Protein
Product Specifications
Background
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse tripartite motif-containing 29 (Trim29), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
1110047J21Rik; 2810431N19Rik; 4732461M22Rik; AI119726
Gene ID
72169
UniProt
Q8R2Q0
Accession Number mRNA
NM_023655
Chromosomal Location
9 A5.1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
65.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Trim29
Species
Mouse
Protein ID
NP_076144
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/72169
Uniprot URL
https://www.uniprot.org/uniprot/Q8R2Q0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_023655
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_076144
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