Ppm1d (BC023492) Mouse Recombinant Protein
Product Specifications
Background
Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (By similarity) . Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (PubMed:24135283) .[UniProtKB/Swiss-Prot Function]
Synonyms
AV338790; Wip1
Gene ID
53892
UniProt
Q9QZ67
Accession Number mRNA
BC023492
Chromosomal Location
11 51.34 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
74.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ppm1d
Species
Mouse
Overview
Purified recombinant protein of Mouse protein phosphatase 1D magnesium-dependent, delta isoform (cDNA clone MGC:32306 IMAGE:5026376), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/53892
Uniprot URL
https://www.uniprot.org/uniprot/Q9QZ67
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC023492
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