Dach2 (NM_001142570) Mouse Recombinant Protein
Product Specifications
Background
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain.[UniProtKB/Swiss-Prot Function]
Synonyms
9430028N04Rik
Gene ID
93837
UniProt
Q925Q8
Accession Number mRNA
NM_001142570
Chromosomal Location
X 49.13 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
65.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Dach2
Species
Mouse
Protein ID
NP_001136042
Overview
Purified recombinant protein of Mouse dachshund family transcription factor 2 (Dach2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/93837
Uniprot URL
https://www.uniprot.org/uniprot/Q925Q8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001142570
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001136042
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