Ncbp3 (NM_025818) Mouse Recombinant Protein
Product Specifications
Background
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858) .[UniProtKB/Swiss-Prot Function]
Synonyms
1200014J11Rik; C78393; C130061O14Rik
Gene ID
66874
UniProt
Q8BZR9
Accession Number mRNA
NM_025818
Chromosomal Location
11 B4
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
70.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ncbp3
Species
Mouse
Protein ID
NP_080094
Overview
Purified recombinant protein of Mouse nuclear cap binding subunit 3 (Ncbp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/66874
Uniprot URL
https://www.uniprot.org/uniprot/Q8BZR9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_025818
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_080094
Curated Selection
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