Sh2b2 (NM_018825) Mouse Recombinant Protein
Selected Variant
PM45471M5
Size: 20 µg
Product Specifications
Background
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse SH2B adaptor protein 2 (Sh2b2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
Aps
Gene ID
23921
UniProt
Q9JID9
Accession Number mRNA
NM_018825
Chromosomal Location
5 G2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
66.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Sh2b2
Species
Mouse
Protein ID
NP_061295
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23921
Uniprot URL
https://www.uniprot.org/uniprot/Q9JID9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018825
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_061295
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