Ubash3b (NM_176860) Mouse Recombinant Protein

Product Specifications

Background

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse ubiquitin associated and SH3 domain containing, B (Ubash3b), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

2810457I06Rik; BB125008; p70; TULA-2

Gene ID

72828

UniProt

Q8BGG7

Accession Number mRNA

NM_176860

Chromosomal Location

9 A5.1

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

71.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.