Ttll12 (NM_183017) Mouse Recombinant Protein
Product Specifications
Background
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) . Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.[UniProtKB/Swiss-Prot Function]
Synonyms
BC055368; D430005B17
Gene ID
223723
UniProt
Q3UDE2
Accession Number mRNA
NM_183017
Chromosomal Location
15 E1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
74 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ttll12
Species
Mouse
Protein ID
NP_898838
Overview
Purified recombinant protein of Mouse tubulin tyrosine ligase-like family, member 12 (Ttll12), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/223723
Uniprot URL
https://www.uniprot.org/uniprot/Q3UDE2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_183017
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_898838
Curated Selection
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