Lrwd1 (NM_027891) Mouse Recombinant Protein
Product Specifications
Background
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity) . Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.[UniProtKB/Swiss-Prot Function]
Synonyms
1200011O22Rik; AU042569; AW548074; Orca
Gene ID
71735
UniProt
Q8BUI3
Accession Number mRNA
NM_027891
Chromosomal Location
5 G2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
71.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Lrwd1
Species
Mouse
Protein ID
NP_082167
Overview
Purified recombinant protein of Mouse leucine-rich repeats and WD repeat domain containing 1 (Lrwd1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/71735
Uniprot URL
https://www.uniprot.org/uniprot/Q8BUI3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_027891
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_082167
Curated Selection
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