Arhgap24 (NM_146161) Mouse Recombinant Protein
Product Specifications
Background
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
0610025G21Rik
Gene ID
231532
UniProt
Q8C4V1
Accession Number mRNA
NM_146161
Chromosomal Location
5 E5
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
73.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Arhgap24
Species
Mouse
Protein ID
NP_666273
Overview
Purified recombinant protein of Mouse Rho GTPase activating protein 24 (Arhgap24), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/231532
Uniprot URL
https://www.uniprot.org/uniprot/Q8C4V1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_146161
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_666273
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