Pecam1 (NM_001032378) Mouse Recombinant Protein

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity) . Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity) . Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity) . Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity) . Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity) . Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity) . Modulates bradykinin receptor BDKRB2 activation (By similarity) . Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity) . Induces susceptibility to atherosclerosis (PubMed:19048083) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse platelet/endothelial cell adhesion molecule 1 (Pecam1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug