Shkbp1 (NM_138676) Mouse Recombinant Protein

Product Specifications

Background

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation (PubMed:21830225) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse Sh3kbp1 binding protein 1 (Shkbp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

B930062H15Rik; Sb1

Gene ID

192192

UniProt

Q6P7W2

Accession Number mRNA

NM_138676

Chromosomal Location

7 A3

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

76.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.