C2cd2l (NM_027909) Mouse Recombinant Protein

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI (4,5) P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity) . It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity) . Plays a key role in the coordination of Ca (2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (By similarity) . In response to elevation of cytosolic Ca (2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (By similarity) . Positively regulates insulin secretion in response to glucose (PubMed:24012759) . Phosphatidylinositol transfer to the cell membrane allows replenishment of PI (4,5) P2 pools and calcium channel opening, priming a new population of insulin granules (By similarity) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Mouse C2 calcium-dependent domain containing 2-like (C2cd2l), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.