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Ncstn (NM_021607) Mouse Recombinant Protein

Product Specifications

Background

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse nicastrin (Ncstn), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

9430068N19Rik; AA727311; Aph2; D1Dau13e; Kiaa0253; mKIAA0253; Nct

Gene ID

59287

UniProt

P57716

Accession Number mRNA

NM_021607

Chromosomal Location

1 79.54 cM

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

78.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

Ncstn

Species

Mouse

Protein ID

NP_067620

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/59287

Uniprot URL

https://www.uniprot.org/uniprot/P57716

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_021607

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_067620

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