Ncstn (NM_021607) Mouse Recombinant Protein
Product Specifications
Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse nicastrin (Ncstn), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
9430068N19Rik; AA727311; Aph2; D1Dau13e; Kiaa0253; mKIAA0253; Nct
Gene ID
59287
UniProt
P57716
Accession Number mRNA
NM_021607
Chromosomal Location
1 79.54 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
78.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ncstn
Species
Mouse
Protein ID
NP_067620
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/59287
Uniprot URL
https://www.uniprot.org/uniprot/P57716
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021607
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_067620
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