Tlk1 (NM_172664) Mouse Recombinant Protein
Product Specifications
Background
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity) . Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse tousled-like kinase 1 (Tlk1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
4930545J15Rik
Gene ID
228012
UniProt
Q8C0V0
Accession Number mRNA
NM_172664
Chromosomal Location
2 C2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
87.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Tlk1
Species
Mouse
Protein ID
NP_766252
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/228012
Uniprot URL
https://www.uniprot.org/uniprot/Q8C0V0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_172664
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_766252
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