Arnt (NM_001037737) Mouse Recombinant Protein
Product Specifications
Background
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (By similarity) . The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (PubMed:26245371, PubMed:27782878) . The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820) .[UniProtKB/Swiss-Prot Function]
Synonyms
BHLHe2; D3Ertd557e; Drnt; ESTM42; Hif1b; mKIAA4051; W08714
Gene ID
11863
UniProt
P53762, Q3ULM2
Accession Number mRNA
NM_001037737
Chromosomal Location
3 40.74 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
87 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Arnt
Species
Mouse
Protein ID
NP_001032826
Overview
Purified recombinant protein of Mouse aryl hydrocarbon receptor nuclear translocator (Arnt), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/11863
Uniprot URL
https://www.uniprot.org/uniprot/P53762
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001037737
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001032826
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6287515-01 0.2 mL
COG2, NT (COG2, LDLC, Conserved oligomeric Golgi complex subunit 2, Component of oligomeric Golgi complex 2, Low density lipoprotein receptor defect C-complementing protein) (AP)
Ask
View Details MBS6287515-02 5x 0.2 mL
COG2, NT (COG2, LDLC, Conserved oligomeric Golgi complex subunit 2, Component of oligomeric Golgi complex 2, Low density lipoprotein receptor defect C-complementing protein) (AP)
Ask
View Details 
