Agtpbp1 (BC060633) Mouse Recombinant Protein
Product Specifications
Background
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell differentiation, accumulation of tubulin polyglutamylation causing neurodegeneration.[UniProtKB/Swiss-Prot Function]
Synonyms
Nna1, 4930445M19Rik, 1700020N17Rik
Gene ID
67269
UniProt
Q641K1
Accession Number mRNA
BC060633
Chromosomal Location
13
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
168.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Agtpbp1
Species
Mouse
Overview
Purified recombinant protein of Mouse ATP/GTP binding protein 1 (cDNA clone MGC:79186 IMAGE:6848599), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/67269
Uniprot URL
https://www.uniprot.org/uniprot/Q641K1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC060633
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