Nfatc4 (NM_023699) Mouse Recombinant Protein

Ca (2+) -regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:17198697) . Along with NFATC3, involved in embryonic heart development (PubMed:12750314, PubMed:17198697) . Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (PubMed:12750314) . Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714) . Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity) . Binds to and transactivates AGTR2 gene promoter (PubMed:17198697) . Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (PubMed:22586092) . In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (PubMed:18354019) . Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) . Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity) . Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable) . In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity) . Binds to PPARG and REG3G gene promoters (PubMed:17198697) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug