Unc5b (BC057560) Mouse Recombinant Protein

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity) . Functions as netrin receptor that negatively regulates vascular branching during angiogenesis (PubMed:15510105) . Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (PubMed:15510105) . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Mouse unc-5 homolog B (C. elegans) (cDNA clone MGC:66787 IMAGE:6417563), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.