Card14 (NM_130886) Mouse Recombinant Protein
Product Specifications
Background
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.[UniProtKB/Swiss-Prot Function]
Synonyms
Bimp2; CARMA2
Gene ID
170720
UniProt
Q99KF0
Accession Number mRNA
NM_130886
Chromosomal Location
11 E2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
113.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Card14
Species
Mouse
Protein ID
NP_570956
Overview
Purified recombinant protein of Mouse caspase recruitment domain family, member 14 (Card14), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/170720
Uniprot URL
https://www.uniprot.org/uniprot/Q99KF0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_130886
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_570956
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