Slc12a5 (NM_020333) Mouse Recombinant Protein
Product Specifications
Background
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl (-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl (-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse solute carrier family 12, member 5 (Slc12a5), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
KCC2; mKIAA1176
Gene ID
57138
UniProt
Q91V14, A0A076FSX1
Accession Number mRNA
NM_020333
Chromosomal Location
2 H3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
124 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Slc12a5
Species
Mouse
Protein ID
NP_065066
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/57138
Uniprot URL
https://www.uniprot.org/uniprot/Q91V14
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_020333
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_065066
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