Kdm6a (NM_009483) Mouse Recombinant Protein
Product Specifications
Background
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity) . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (PubMed:21095589) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse lysine (K) -specific demethylase 6A (Kdm6a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
Utx
Gene ID
22289
UniProt
O70546, Q3TPN3
Accession Number mRNA
NM_009483
Chromosomal Location
X 13.45 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
157.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Kdm6a
Species
Mouse
Protein ID
NP_033509
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/22289
Uniprot URL
https://www.uniprot.org/uniprot/O70546
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_009483
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_033509
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