Fbxo3 (NM_020593) Mouse Recombinant Protein
Product Specifications
Background
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein) -type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
1200002G09Rik; 1700026K02Rik; AI046358; Fba
Gene ID
57443
UniProt
Q9DC63, Q9CVV6
Accession Number mRNA
NM_020593
Chromosomal Location
2 E2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
47.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Fbxo3
Species
Mouse
Protein ID
NP_065618
Overview
Purified recombinant protein of Mouse F-box protein 3 (Fbxo3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/57443
Uniprot URL
https://www.uniprot.org/uniprot/Q9DC63
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_020593
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_065618
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