Lrrc32 (NM_001113379) Mouse Recombinant Protein
Product Specifications
Background
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:25127859) . Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:25127859, PubMed:28912269) . Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (By similarity) . Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:25127859) . Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (PubMed:28912269) .[UniProtKB/Swiss-Prot Function]
Synonyms
AI426318; D7H11S833E; D11S833Eh; EG434215; Garp
Gene ID
434215
UniProt
G3XA59
Accession Number mRNA
NM_001113379
Chromosomal Location
7 53.86 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
72.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Lrrc32
Species
Mouse
Protein ID
NP_001106850
Overview
Purified recombinant protein of Mouse leucine rich repeat containing 32 (Lrrc32), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/434215
Uniprot URL
https://www.uniprot.org/uniprot/G3XA59
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001113379
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001106850
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