Osbp (NM_001033174) Mouse Recombinant Protein
Product Specifications
Background
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.[UniProtKB/Swiss-Prot Function]
Synonyms
1110018F06Rik; AW559088; mKIAA4220
Gene ID
76303
UniProt
Q3B7Z2
Accession Number mRNA
NM_001033174
Chromosomal Location
19 8.58 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
89.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Osbp
Species
Mouse
Protein ID
NP_001028346
Overview
Purified recombinant protein of Mouse oxysterol binding protein (Osbp), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/76303
Uniprot URL
https://www.uniprot.org/uniprot/Q3B7Z2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001033174
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001028346
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