Ptprn2 (NM_011215) Mouse Recombinant Protein

Plays a role in vesicle-mediated secretory processes (PubMed:21732083) . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083) . Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083) . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463) . Required to maintain normal levels of renin expression and renin release (PubMed:19019914) . May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328) . Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI (4,5) P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity) . Regulates PI (4,5) P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI (4,5) P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Mouse protein tyrosine phosphatase, receptor type, N polypeptide 2 (Ptprn2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.