Mxra8 (NM_024263) Mouse Recombinant Protein

Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220) . Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072) . Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581) . Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220) . Stimulates formation of primary cilia in chondrocytes (PubMed:29702220) . Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220) . Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity) . Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity) . Also inhibits VTN (vitronectin) -mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity) . May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.