Klhl40 (NM_028202) Mouse Recombinant Protein
Product Specifications
Background
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:25940086) . The BCR (KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (PubMed:25940086) . Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (PubMed:24960163) .[UniProtKB/Swiss-Prot Function]
Synonyms
2310024D23Rik; Kbtbd5
Gene ID
72330
UniProt
Q9D783, A0A0R4J166
Accession Number mRNA
NM_028202
Chromosomal Location
9 F4
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
70.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Klhl40
Species
Mouse
Protein ID
NP_082478
Overview
Purified recombinant protein of Mouse kelch-like 40 (Klhl40), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/72330
Uniprot URL
https://www.uniprot.org/uniprot/Q9D783
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_028202
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_082478
Curated Selection
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