Def6 (NM_027185) Mouse Recombinant Protein
Product Specifications
Background
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of systemic autoimmunity (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
2410003F05Rik; 6430538D02Rik; AV094905; Ibp; Slat; Slat2; Slat6
Gene ID
23853
UniProt
Q8C2K1, A0A0R4IZX1
Accession Number mRNA
NM_027185
Chromosomal Location
17 A3.3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
73.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Def6
Species
Mouse
Protein ID
NP_081461
Overview
Purified recombinant protein of Mouse differentially expressed in FDCP 6 (Def6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23853
Uniprot URL
https://www.uniprot.org/uniprot/Q8C2K1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_027185
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_081461
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