Sema4a (NM_001163491) Mouse Recombinant Protein

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:20043131, PubMed:17318185) . Regulates glutamatergic and GABAergic synapse development (PubMed:29981480) . Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480) . Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988) . Promotes phosphorylation of TIMD2 (PubMed:12374982) . Inhibits angiogenesis (PubMed:17318185) . Promotes axon growth cone collapse (PubMed:20043131) . Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug