Mcu (NM_001033259) Mouse Recombinant Protein

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685886, PubMed:23900286, PubMed:24212091) . Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity) . Activity is regulated by MICU1 and MICU2 (By similarity) . At low Ca (2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca (2+) levels MICU1 increases MCU activity (By similarity) . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity) . Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity) . While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:26119742, PubMed:26119731, PubMed:25603276) . Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731) . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity) . Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (PubMed:25732818) . Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (PubMed:26644474) . Involved in antigen processing and presentation (PubMed:25251370) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.