Grin3a (NM_001033351) Mouse Recombinant Protein
Product Specifications
Background
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth (By similarity) . By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (PubMed:24297929) . May also play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse glutamate receptor ionotropic, NMDA3A (Grin3a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
6430537F04; A830097C19Rik; mKIAA1973; NMDAR-L; NR3A
Gene ID
242443
UniProt
A2AIR4
Accession Number mRNA
NM_001033351
Chromosomal Location
4 B1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
125.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Grin3a
Species
Mouse
Protein ID
NP_001028523
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/242443
Uniprot URL
https://www.uniprot.org/uniprot/A2AIR4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001033351
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001028523
Curated Selection
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