Grin3a (NM_001033351) Mouse Recombinant Protein

Product Specifications

Background

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth (By similarity) . By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (PubMed:24297929) . May also play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse glutamate receptor ionotropic, NMDA3A (Grin3a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

6430537F04; A830097C19Rik; mKIAA1973; NMDAR-L; NR3A

Gene ID

242443

UniProt

A2AIR4

Accession Number mRNA

NM_001033351

Chromosomal Location

4 B1

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

125.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.