Kctd21 (NM_001039039) Mouse Recombinant Protein

Product Specifications

Background

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse potassium channel tetramerisation domain containing 21 (Kctd21), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

EG622320

Gene ID

622320

UniProt

Q3URF8, B2RTJ2

Accession Number mRNA

NM_001039039

Chromosomal Location

7 E1

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

29.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.