Kctd21 (NM_001039039) Mouse Recombinant Protein
Product Specifications
Background
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) .[UniProtKB/Swiss-Prot Function]
Synonyms
EG622320
Gene ID
622320
UniProt
Q3URF8, B2RTJ2
Accession Number mRNA
NM_001039039
Chromosomal Location
7 E1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
29.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Kctd21
Species
Mouse
Protein ID
NP_001034128
Overview
Purified recombinant protein of Mouse potassium channel tetramerisation domain containing 21 (Kctd21), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/622320
Uniprot URL
https://www.uniprot.org/uniprot/Q3URF8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001039039
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001034128
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