Grb14 (NM_016719) Mouse Recombinant Protein
Selected Variant
PM43610M5
Size: 20 µg
Product Specifications
Background
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse growth factor receptor bound protein 14 (Grb14), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AI505286
Gene ID
50915
UniProt
Q9JLM9, A2ASX2
Accession Number mRNA
NM_016719
Chromosomal Location
2 C1.3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
60.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Grb14
Species
Mouse
Protein ID
NP_057928
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/50915
Uniprot URL
https://www.uniprot.org/uniprot/Q9JLM9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016719
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057928
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