Dusp6 (NM_026268) Mouse Recombinant Protein

Product Specifications

Background

Inactivates MAP kinases. Has a specificity for the ERK family (By similarity) . Plays an important role in alleviating acute postoperative pain (PubMed:24155322, PubMed:28405172) . Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (PubMed:24155322) . Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (PubMed:28405172) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse dual specificity phosphatase 6 (Dusp6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

1300019I03Rik; MKP-3; MKP3; PYST1

Gene ID

67603

UniProt

Q9DBB1

Accession Number mRNA

NM_026268

Chromosomal Location

10 D1

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

42.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.