Itgae (NM_172944) Mouse Recombinant Protein
Product Specifications
Background
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.[UniProtKB/Swiss-Prot Function]
Synonyms
A530055J10; alpha-E1; alpha-M290; aM290; CD103
Gene ID
16407
UniProt
Q8BS01
Accession Number mRNA
NM_172944
Chromosomal Location
11 45.22 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
115.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Itgae
Species
Mouse
Overview
Purified recombinant protein of Mouse integrin alpha E, epithelial-associated (Itgae), transcript variant 2, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/16407
Uniprot URL
https://www.uniprot.org/uniprot/Q8BS01
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_172944
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